Trusted Resources: Education
Scientific literature and patient education texts
Nutritional, Gastrointestinal and Endo-Metabolic Challenges in The Management of Children with Spinal Muscular Atrophy Type 1
source: Nutrients
year: 2021
authors: Antonio Corsello, Lorenzo Scatigno, Martina Chiara Pascuzzi, Valeria Calcaterra, Dario Dilillo, Sara Vizzuso, Gloria Pelizzo, et al.
summary/abstract:The management of patients with spinal muscular atrophy type 1 (SMA1) is constantly evolving. In just a few decades, the medical approach has switched from an exclusively palliative therapy to targeted therapy, transforming the natural history of the disease, improving survival time and quality of life, and creating new challenges and goals. Many nutritional problems, gastrointestinal disorders, and metabolic and endocrine alterations are commonly identified in patients affected by SMA1 during childhood and adolescence. For this reason, a proper pediatric multidisciplinary approach is then required in the clinical care of these patients, with a specific focus on the prevention of the most common complications. The purpose of this narrative review is to provide the clinician with a practical and usable tool for SMA1 patients’ care, through a comprehensive insight into the nutritional, gastroenterological, metabolic, and endocrine management of SMA1. Considering the possible horizons opened thanks to new therapeutic frontiers, nutritional and endo-metabolic surveillance is a crucial element to be considered for proper clinical care of these patients.
organization: University of Milan, Italy; University of Pavia, Italy; Children’s Hospital Vittore Buzzi, Milan, Italy; “Aldo Moro” University of Bari, Italy; University of Foggia, Italy
DOI: 10.3390/nu13072400
read more
Related Content
-
Sofia’s Story – Johns Hopkin’sOn the morning of Friday, Aug. 23, 2019,...
-
Spine Surgery Effective in SMA Type 1 Children, But Not Without RisksSurgery to correct kyphoscoliosis — a ...
-
Magnetic Resonance Reveals Mitochondrial Dysfunction and Muscle Remodelling in Spinal Muscular AtrophyGenetic therapy has changed the prognosi...
-
H-NMR-Based Metabolic Profiling Identifies Non-Invasive Diagnostic and Predictive Urinary Fingerprints in 5q Spinal ...5q spinal muscular atrophy (SMA) is a di...
-
Nusinersen: A Review in 5q Spinal Muscular AtrophySurvival motor neuron 1 (SMN1), located ...
-
Kathie Bishop, PhDKathie Bishop is a Ph.D level neuroscien...
-
Patient of the Month: GiannaAfter noticing that her daughter was una...